The complexity of the immune system involves many molecules and, therefore, genes with important variations in their regulation, expression and response to different stimuli. The main objective of the course is the acquisition by the student of the molecular knowledge of the immune system key genes and molecules. Murine and human Major Histocompatibility Complex molecules, Natural Killer cell receptors, and diversity, genetics and functions of adaptive immunity receptors: immunoglobulins and T cell receptors. Students will understand how generation of antigen receptor diversity, clonality, polymorphism, and antigen processing and presentation molecules influence the immune response and their applications to the diagnostic and specific therapies. He will also learn how to use relevant bioinformatics to study the genes of the immune system.

Students understand the main mechanisms of tolerance relevant to autoimmune disease. After the course students will be able to use immunopathology reasoning to understand clinical cases of autoimmunity. They know which immunology tests can help in the diagnosis of the main autoimmune diseases. They have the capability to discuss research results at a journal club or at a research meeting. They are able to design a strategy to approach research in autoimmune diseases.

This module provides an overview of the mechanisms that regulate the activity of the immune system. Students understand the essentials of innate and adaptive immune responses and their regulation from recognition to the effective destruction of pathogens or management of other injury to the body. They learn various molecules and their receptors involved in regulation and communication that characterize the different types of immune response. As immune responses are generally very short duration it is necessary to know the mechanisms that inhibit such responses. This includes a number of regulatory cells and molecules with suppressive or tolerogenic effects. Finally, students will discover the immuno-metabolism and neuro-immunology interfaces.

Students of the LIVE Master need to understand that one of the main features of the immune system, compared to most of the physiological systems existing in living beings, is its diverse nature and its structure. Students learn the location and topology of the different anatomical components of the immune system and understand their interconnection with the rest of the body. They come to a comprehensive understanding of the location, distribution and structure of the different components of the immune system and how they interact. After the course students will understand the anatomy of the immune system and its normal functioning as a global system, understand the concept of haematopoiesis as a generator of immune cell diversity, understand the specific characteristics of the immune response at different locations and explain the mechanisms driving cell traffic and their relationship with the immune response.

This course allows students to achieve a full understanding of the relationship between the type of immune response and characteristics of each pathogen, including the way and the anatomical site of entry, the effector mechanisms of response and evasion. Experts cover innate and adaptive immune response to extracellular and intracellular bacteria, viruses, unicellular (Plasmodium) and multicellular (Helminth) parasites. Students understand the relationships between opportunistic pathogens and its host and also how genetic defects of specific immune genes lead to pathogen-specific infections.

After the course students will be able to use immunopathology reasoning to understand clinical cases of immunodeficiency. They know which immunology tests can help in the diagnosis of the main
immunodeficiency diseases. They are familiar with the main types of therapy applied to immunodeficiency diseases. They know the differences between primary and secondary immunodeficiencies and can illustrate with examples. They have the capability to discuss research results at a journal club or at a research meeting. They know what they can expect from vaccination to immunodeficient individuals.

The goal of this teaching unit is to improve the student’s proficiency level, taking into account his or her previous knowledge of the language. The student is asked to take a placement test on arrival at the Language Service so as to be placed in the adequate course, according to his or her level. Spanish and French will be taught in person. Students who know Spanish and French can follow online courses of any of the following European Languages: German, Italian or Portuguese.

This course introduces students to diseases induced by immune system dysfunction with special emphasis on immune-mediated diseases. Students apply their newly acquired concepts on the mechanisms of the normal immune response to these diseases. Students also learn the principles of experimental immunopathology and the main diagnostic tests currently used in the clinical immunology laboratory. Students understand the main mechanisms of the immune-mediated diseases including immunodeficiency, hypersensitivity and autoimmunity. They study mechanisms that determine rejection or tolerance to allogeneic graft of organs or cells. In clinical immunology, they discover the tools helpful to diagnose immune-mediated diseases. They can use immunopathology concepts for reasoning to understand clinical cases and to discuss research results.

The Receptor Signalling course focuses on cell signalling architecture and major signalling pathways in innate and adaptive immunity. Specific examples of signalling pathways associated with pathology or mediating therapeutic processes are presented. The students analyse and comment on recent relevant scientific literature concerning a signalling process. Teamwork is promoted. Students delve into a dozen signalling pathways to understand cell signalling as an integrative process underlying the modulation of immune cell activities.