Student authors

As part of the LIVE Master programme, the students are trained to effectively and independently conduct research, interpret results, and write research articles for publication. Here, you find samples of research projects conducted by LIVE students during their 6-month end-of-studies semester 4 internship giving rise to Master thesis and sometimes to publications in peer-reviewed journals.

Master’s thesis

During the semester 4 of the Erasmus LIVE programme, the students undergo a 6-month end-of-studies full-time internship where they carry out professional work. From this period, the Master students must write their Master thesis to report their research or other professional activities such as production, quality, management, etc, taking some distance to provide written analysis, meaningful discussion and insightful perspectives. Finally, they defend their Master thesis in front of a five-member professional jury. Overall, they hone their professional skills to integrate the world of vaccinology. Master thesis can deal with different themes, according to the internship professional environment, such as:

Bioinformatics

Single-cell transcriptomics to explore the immune system in healthy and/or vaccinated animals

Computational investigation of the immunological landscape of SARS-CoV-2 intrahost mutations

Epidemiology

Emerging Diseases and Epidemic Readiness: Understanding the Role of Vaccines and Vaccination

Natural antibody response against group B streptococcus in a cohort of non-pregnant women

High IL-13 serum levels among people with mild COVID-19 disease: laboratory and data analyses of a patient subgroup from the prospective, longitudinal predi-COVID cohort study in Luxembourg

Using Guthrie cards for a serosurveillance study of maternally-derived antibody against Group B Streptococcus (GBS)

The changing epidemiology of Tick-borne encephalitis (TBE) The serology of TBE: A critical analysis of available methods and their possible use as a correlate of protection

Public health and vaccine communication

Driving the Cultural Transformation of GSK Vaccines to Foster Portfolio Expansion in China

A Look at Covid-19 and Covid-19 Vaccine Information Dissemination and Understanding in Barcelona both in Schools and Amongst the General Public

Medical Science Liaison Support

Knowledge, attitude and perception to participation in vaccine clinical trials among French general population and specific subgroups (healthcare workers, elderly): evaluation and translation into an intervention to increase participation in vaccine preventive trials.

Achieving equitable vaccine access during pandemics - the road ahead after Covid-19

Assessing COVID-19 vaccine acceptability in the general public, especially adults and elderly, in Oman

Assessing knowledge and acceptability of COVID-19 vaccines among healthcare workers in Oman

Understanding the acceptability of vaccines and potential barriers to vaccination in general and specifically to HPV vaccines in the general population in Indonesia

Analysis of the design and implementation of a social and behavior change intervention for vaccine confidence

Immunology

Towards a Universal Rhinovirus Vaccine: Characterisation of Antibody Responses Induced by Conserved Capsid Epitopes

In vitro and in vivo characterization of live YF17D-based Zika virus vaccine candidate

Immunological analysis of response generated from first-in-human transmission blocking malaria vaccine trial

Investigation of Non-Coding RNAs In Chronic Inflammatory Skin Diseasesdidate

Mechanisms of dendritic cell activation in health and disease

Preclinical analysis of the immune modulatory functions of an RNA-based adjuvant on primary human immune cells

Cell Biology and Vaccine Validation

Towards Structure-Guided Vaccine Design for Porcine Reproductive and Respiratory Syndrome: Isolation and Characterisation of Virus-Neutralising Monoclonal Antibodies

Ex-vivo characterization of therapeutic strategies to restore sepsis-induced T cell alterations

Developing a production process for a Phlebotomus papatasi-derived salivary protein suitable for a vaccine target antigen against Leishmaniasis

Testing interaction of a novel mucosal vaccine platform for SARS-Cov2 with human tonsil cells

Development of immunoassays for the evaluation of the immune response to an anti-alpha-synucleinvaccine in a Phase 2 clinical trial

Molecular and cellular biology

Establishment of an in vitro cytotoxicity assay

Investigating Immunometabolism From a Novel Point of View: Single Cell Metabolism

Host-parasite interactions, with special focus of the immunopathogenesis of neurotoxoplasmosis

Crosstalk between C-type lectin receptor MINCLE and cellular autophagy

Structural characterization of HIV Env in complex with a neutralising antibody

Autophagy modulation by Mycobacterium tuberculosis lipids

Construction of an Unmarked recombinant BCG expressing the LTAK63 adjuvant as tuberculosis vaccine

System biology

Utilising Whole Genome Sequencing and RNAseq of the Major Malaria Vector Species Complex to Design Diagnostics for Use in Endemic Settings

Single-cell transcriptomic characterization of the vaccine-induced temporal immune events associated with protection against African swine fever virus

Identifying links between metabolism and epigenetics in the context of cancer-associated myeloid cells

Antimicrobial resistance

Determination of the in-vivo minimum selection concentration of ciprofloxacin and azithromycin for N. gonorrhoeae and N. subflava in the Galleria mellonella model

Infection and immunity

Identification of cytosolic or nuclear protein ligands of Mycobacterium tuberculosis lipids in macrophages

Elucidating the Role of p27 Specific Antibodies in Protective Immunity Against RSV Infection

Investigating the Interaction of HPV (Pseudo)Virions and Hpv-Specific Antibodies Using First-Void Urine as Liquid Biopsy

Understanding the Biology of Plasmodium in the Mosquito Vector of Malaria

Validation of circulatory biomarkers prevously identified in granuloma tissue of TB patients

Screening new virulence factors in Streptococcus pneumoniae by Crispr interference

Here are two master theses written by LIVE students Nicolás Gutiérrez Melo and Sergio Castillo:

Poster Presentation

Perception of Dengue and Acceptability of Dengue vaccine in University students

Simultaneous carriage of multiple serotypes of Streptococcus Group B: a systematic review

Optimization of methods in preparation for a human infection model for Group b Streptococcus (the TIMING study)

Publications

Non-specific Effects of vaccines illustrated through the BCG Example: From Observation to Demonstration

Tailoring mRNA vaccine to Balance innate/adaptive immune response

The lipid virulence factors of mycobacterium tuberculosis exert multi-layered control over autophagy-related pathways in infected human macrophages

Association of DNA-Methylation Profiles with Immune Responses Elicited in Breast Cancer Patients Immunized with a Carbohydrate-Mimicking Peptide: A Pilot Study

Bovine herpesvirus-4-vectored delivery of Nipah virus Glycoproteins enhances T cell Immunogenicity in pigs

Antibody responses to the RTS,S/ASO1E vaccine and plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique

Knowledge, Attitude, and Acceptability of COVID-19 Vaccine in Oman: A Cross-sectional Study

A scalable and reproducible manufacturing process for Phlebotomus papatasi salivary protein PpSP15, a vaccine candidate for leishmaniasis

Predictors of influenza severity among hospitalized adults with laboratory confirmed influenza: Analysis of nine influenza seasons from the Valencia region, Spain

The Changing Epidemio-logy of Tick-Borne Ence-phalitis (TBE)

Knowledge, Attitude and Acceptability of the Human Papilloma Virus Vaccine and Vaccination Among University Students in Indonesia

The formal ability of countries to deliver high-quality vaccination services: Introducing the Country Vaccination Score (CVS)

Thinking Cancer

The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group

Towards the future exploration of mucosal mRNA vaccines against emerging viral diseases; lessons from existing next-generation mucosal vaccine strategies

Student authors

Student authors

Master’s thesis

Bioinformatics

Single-cell transcriptomics to explore the immune system in healthy and/or vaccinated animals

Computational investigation of the immunological landscape of SARS-CoV-2 intrahost mutations

Epidemiology

Emerging Diseases and Epidemic Readiness: Understanding the Role of Vaccines and Vaccination

Natural antibody response against group B streptococcus in a cohort of non-pregnant women

High IL-13 serum levels among people with mild COVID-19 disease: laboratory and data analyses of a patient subgroup from the prospective, longitudinal predi-COVID cohort study in Luxembourg

Using Guthrie cards for a serosurveillance study of maternally-derived antibody against Group B Streptococcus (GBS)

The changing epidemiology of Tick-borne encephalitis (TBE) The serology of TBE: A critical analysis of available methods and their possible use as a correlate of protection

Public health and vaccine communication

Driving the Cultural Transformation of GSK Vaccines to Foster Portfolio Expansion in China

A Look at Covid-19 and Covid-19 Vaccine Information Dissemination and Understanding in Barcelona both in Schools and Amongst the General Public

Medical Science Liaison Support

Knowledge, attitude and perception to participation in vaccine clinical trials among French general population and specific subgroups (healthcare workers, elderly): evaluation and translation into an intervention to increase participation in vaccine preventive trials.

Achieving equitable vaccine access during pandemics - the road ahead after Covid-19

Assessing COVID-19 vaccine acceptability in the general public, especially adults and elderly, in Oman

Assessing knowledge and acceptability of COVID-19 vaccines among healthcare workers in Oman

Understanding the acceptability of vaccines and potential barriers to vaccination in general and specifically to HPV vaccines in the general population in Indonesia

Analysis of the design and implementation of a social and behavior change intervention for vaccine confidence

Immunology

Towards a Universal Rhinovirus Vaccine: Characterisation of Antibody Responses Induced by Conserved Capsid Epitopes

In vitro and in vivo characterization of live YF17D-based Zika virus vaccine candidate

Immunological analysis of response generated from first-in-human transmission blocking malaria vaccine trial

Investigation of Non-Coding RNAs In Chronic Inflammatory Skin Diseasesdidate

Mechanisms of dendritic cell activation in health and disease

Preclinical analysis of the immune modulatory functions of an RNA-based adjuvant on primary human immune cells

Cell Biology and Vaccine Validation

Towards Structure-Guided Vaccine Design for Porcine Reproductive and Respiratory Syndrome: Isolation and Characterisation of Virus-Neutralising Monoclonal Antibodies

Ex-vivo characterization of therapeutic strategies to restore sepsis-induced T cell alterations

Developing a production process for a Phlebotomus papatasi-derived salivary protein suitable for a vaccine target antigen against Leishmaniasis

Testing interaction of a novel mucosal vaccine platform for SARS-Cov2 with human tonsil cells

Development of immunoassays for the evaluation of the immune response to an anti-alpha-synucleinvaccine in a Phase 2 clinical trial

Molecular and cellular biology

Establishment of an in vitro cytotoxicity assay

Investigating Immunometabolism From a Novel Point of View: Single Cell Metabolism

Host-parasite interactions, with special focus of the immunopathogenesis of neurotoxoplasmosis

Crosstalk between C-type lectin receptor MINCLE and cellular autophagy

Structural characterization of HIV Env in complex with a neutralising antibody

Autophagy modulation by Mycobacterium tuberculosis lipids

Construction of an Unmarked recombinant BCG expressing the LTAK63 adjuvant as tuberculosis vaccine

System biology

Utilising Whole Genome Sequencing and RNAseq of the Major Malaria Vector Species Complex to Design Diagnostics for Use in Endemic Settings

Single-cell transcriptomic characterization of the vaccine-induced temporal immune events associated with protection against African swine fever virus

Identifying links between metabolism and epigenetics in the context of cancer-associated myeloid cells

Antimicrobial resistance

Determination of the in-vivo minimum selection concentration of ciprofloxacin and azithromycin for N. gonorrhoeae and N. subflava in the Galleria mellonella model

Infection and immunity

Identification of cytosolic or nuclear protein ligands of Mycobacterium tuberculosis lipids in macrophages

Elucidating the Role of p27 Specific Antibodies in Protective Immunity Against RSV Infection

Investigating the Interaction of HPV (Pseudo)Virions and Hpv-Specific Antibodies Using First-Void Urine as Liquid Biopsy

Understanding the Biology of Plasmodium in the Mosquito Vector of Malaria

Validation of circulatory biomarkers prevously identified in granuloma tissue of TB patients

Screening new virulence factors in Streptococcus pneumoniae by Crispr interference

Poster Presentation

Perception of Dengue and Acceptability of Dengue vaccine in University students

Simultaneous carriage of multiple serotypes of Streptococcus Group B: a systematic review

Optimization of methods in preparation for a human infection model for Group b Streptococcus (the TIMING study)

Publications

Non-specific Effects of vaccines illustrated through the BCG Example: From Observation to Demonstration

Tailoring mRNA vaccine to Balance innate/adaptive immune response

The lipid virulence factors of mycobacterium tuberculosis exert multi-layered control over autophagy-related pathways in infected human macrophages

Association of DNA-Methylation Profiles with Immune Responses Elicited in Breast Cancer Patients Immunized with a Carbohydrate-Mimicking Peptide: A Pilot Study

Bovine herpesvirus-4-vectored delivery of Nipah virus Glycoproteins enhances T cell Immunogenicity in pigs

Antibody responses to the RTS,S/ASO1E vaccine and plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique

Knowledge, Attitude, and Acceptability of COVID-19 Vaccine in Oman: A Cross-sectional Study

A scalable and reproducible manufacturing process for Phlebotomus papatasi salivary protein PpSP15, a vaccine candidate for leishmaniasis

Predictors of influenza severity among hospitalized adults with laboratory confirmed influenza: Analysis of nine influenza seasons from the Valencia region, Spain

The Changing Epidemio-logy of Tick-Borne Ence-phalitis (TBE)

Knowledge, Attitude and Acceptability of the Human Papilloma Virus Vaccine and Vaccination Among University Students in Indonesia

The formal ability of countries to deliver high-quality vaccination services: Introducing the Country Vaccination Score (CVS)

Thinking Cancer

The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group

Towards the future exploration of mucosal mRNA vaccines against emerging viral diseases; lessons from existing next-generation mucosal vaccine strategies

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